软骨下骨在骨关节炎中的病理改变及其机制

Role of the Subchondral Bone in Osteoarthritis

近年来,软骨下骨的改变在骨关节炎(OA)发生和发展中的作用得到了公认。软骨下骨已被认为是有潜力的治疗OA的靶点。本文就软骨下骨在OA中的病理改变及其机制的研究进展进行综述,为OA的治疗提供治疗依据。

Temporomandibular joint osteoarthritis（OA） is the most severe type of temporomandibular joint disorder of the oral and maxillofacial region. This disorder has a high incidence,and its main characteristic is articular cartilage injury,accompanied by changes in the synovium and subchondral bone. The role of the changes in the subchondral bone in the development and progression of OA has attracted attention in recent years,and the importance of the subchondral bone has been recognized. At present,the subchondral bone has been considered a promising target for the treatment of OA. This manuscript summarizes the research progress in the pathological changes of the cartilage bone in OA,and its mechanism,which would be helpful for the treatment of this disease.