替格瑞洛对冠状动脉粥样硬化性心脏病PCI术后患者血小板及血流变的影响

Influence of Ticagrelor on Platelets and Hemorheology of Patients with Coronary Atherosclerotic Cardiopathy after PCI Operation

目的观察及研究替格瑞洛对冠状动脉粥样硬化性心脏病PCI术后患者血小板及血流变的影响程度。方法将2014年1月—2015年7月解放军305医院收治的68例冠状动脉粥样硬化性心脏病PCI术治疗患者根据随机分配的原则分为对照组(氯吡格雷治疗组)34例和观察组(替格瑞洛治疗组)34例。将两组患者治疗前及术后1、2、4周血小板参数、血小板活化指标及血流变指标进行比较。结果治疗前两组患者血小板参数、血小板活化指标及血流变指标均无显著性差异(P>0.05),术后1、2、4周观察组血小板高于对照组,其他血小板参数、血小板活化指标及血流变指标均低于对照组有显著性差异(P<0.05)。结论替格瑞洛可更为有效地改善冠状动脉粥样硬化性心脏病PCI术后患者的血小板及血流变。

Objective To determine the extent to which ticagrelor influences platelets and hemorheology of patients with coronary atherosclerotic cardiopathy after PCI operation.Methods Sixty-eight patients with oronary atherosclerotic cardiopathy who had received PCI operation were evenly randomized into the control group（clopidogrel treatment group）and the observation group（ticagrelor treatment group）.Platelet parameters,plateletactiv ation indexes and hemorheological indexes of the two groups before treatment and one,two and four weeks after operation were compared.Results The platelet parameters,platelet activation indexes and hemorheological indexes of the two groups before treatment were not significantly different（P〈0.05）.Platelets of the observation group at the first,second and forth week after operation were higher than those of the control group,while other platelet parameters,platelet activation indexes and hemorheological indexes were all lower（P〈0.05）.The difference was significant.Conclusion Ticagrelor can more effectively improve the platelets and hemorheology of patients with coronary atherosclerotic cardiopathy after PCI operation.