各系免疫细胞嵌合状态监测在异基因造血干细胞移植后的意义

The significance of chimerism monitor in lineage-specific immune cell populations after allogeneic hematopoietic stem cell transplantation

目前,异基因造血干细胞移植(allo-HSCT)是国内外公认的治疗血液系统恶性肿瘤的最有效手段之一。外周血和骨髓中不同亚型细胞的生物学特征存在差异,allo-HSCT后供、受者免疫细胞嵌合状态演变是一个复杂的过程。移植后供者各种免疫细胞亚群的嵌合状态分析因其极高的敏感度和特异度,在判断allo-HSCT的临床效果、疾病转归、提高移植术后受者生存率等方面发挥着重要的临床指导意义。本文就allo-HSCT后供、受者间各种免疫细胞嵌合状态监测的临床意义作一综述。

Allogeneic hematopoietic stem cell transplantation has been accepted as one of the most effective therapy to treat hematological malignancies at home and abroad. The biological characteristics of immune cell subsets are different from each other,and donor cell chimerism after allogeneic hematopoietic stem cell transplantation can be complicated. Therefore,analyzing of donortype chimerism in lineage-specific immune cell populations plays a significant role in estimating engraftment,predicting disease prognosis and improving survival rate because of its high sensibility and specificity. We reviewed the clinical significance of supervising chimerism in lineage-specific immune cell populations after allogeneic hematopoietic stem cell transplantation.