益生菌代谢中药有效成分的研究进展

Research advance in metabolism of effective ingredients from traditional Chinese medicines by probiotics

中药有效成分得以发挥其药理活性在很大程度上取决于人体内肠道益生菌的微生态环境。益生菌通过影响中药有效成分的代谢、转化、吸收等作用而改变中草药的功效或增添新的内容。益生菌和中药的结合是功能性食品及中药研发的创新点,也是中药现代化研究的新思路。该文简要地综述了国内外肠道益生菌代谢中药主要有效成分的研究进展,中药有效成分对肠道益生菌的调节作用,益生菌在中药中的应用现状,研究和开发益生菌中药产品存在的主要问题和前景分析,旨在为中药发酵工程提供理论指导和实际应用价值。

The pharmacological activity of active ingredients from Chinese medicine depends greatly on the microecological environment of probiotics in the human body.After effective ingredients from traditional Chinese medicines are metabolized or biotransformed by probiotics,their metabolites can increase pharmacological activity,and can be absorbed more easily to improve the bioavailability.Therefore,the combination of Chinese medicines with probiotics is the innovation point in RD of functional food and Chinese medicines,and also a new thinking for the modernization of Chinese medicine.This review summarizes and analyses the research progress on metabolism effects of gut microbiota on Chinese medicines components,the regulating effect of effective ingredients from Chinese medicine on intestinal probiotics,the application status of probiotics in traditional Chinese medicines,and the main problems and prospects in the research and development of Chinese medicines products with probiotic,aiming to provide theoretical guidance and practical value for the fermentation engineering of Chinese herbal medicine.