基于“单味药-药对-复方”多层次的四逆散抗抑郁作用研究进展

Research progress on antidepressant effects of Sini San based on three progressive levels of "single herb,herb-pair,and complicated Chinese herbal formula"

抑郁症是临床上一种病因病机相当复杂的精神类疾病。随着现代社会生活节奏的加快以及生活压力的增大,抑郁症的发病率逐年增长。针对抑郁症,目前临床上常见的是应用五羟色胺再摄取抑制剂类（SSRI）或三环类抗抑郁西药,但因其不良反应大,治疗缓慢且治愈率低,从而不能长期使用。四逆散是临床常用的治疗抑郁症的方剂,始载于张仲景的《伤寒论》,为现代治疗抑郁症的基础方。该文就四逆散中柴胡和白芍单味药,柴胡-白芍药对,以及四逆散复方的抗抑郁作用展开综述,为今后中药复方的研究提供方向和思路。

Depression is a kind of mental illness accompanied by complex etiology and pathogenesis in clinic.With the quickening pace of circadian rhythm and increase of life pressure in modern society,the incidence of depression is increasing year by year.Nowadays,some typical antidepressant Western medicines,such as selective serotonin re-uptake inhibitors（SSRI） and tricyclic antidepressants（TCA）,have been used as the main therapeutic drugs in clinic.Unfortunately,administration of these drugs will result in severe adverse reactions,slow treatments,and low cure rates,thus obviously they can not be used for a long term.Sini San,which originated from Treatise on Febrile Diseases written by Zhang zhongjing,is a prescription widely applied in clinic for curing mental illness and also a basic Chinese herbal formula for modern treatment of depression.This article would review the research progress on antidepressant effects of Sini San based on single herbs of Bupleuri Radix and Paeoniae Radix Alba,herb-pair of Bupleuri Radix-Paeoniae Radix Alba,and formula of Sini San,providing directions and ideas for future research on complicated Chinese herbal formulae.