2型糖尿病患者血清IL-10水平与颈动脉粥样硬化的关系

The relationship between serum IL-10 level of patients with type 2 diabetic mellitus and carotid atherosclerosis

目的探讨2型糖尿病(T2DM)患者血清中白细胞介素(IL)-10表达情况及其与颈动脉粥样硬化的关系。方法回顾性分析2013年5月至2016年12月于武警北京总队第三医院治疗的T2DM患者168例。根据颈动脉内膜中层厚度(IMT)值将患者分为正常组、增厚组及颈动脉粥样硬化斑块形成组(斑块组),选择同期健康体检的志愿者65例作为对照组。比较各组炎症指标、血糖、血脂及其他指标水平,同时分析IL-10与其他检测指标的相关性,分析T2DM患者颈动脉粥样硬化的危险因素。结果与对照组相比,T2DM患者血清中IL-6、血糖、血脂及其他指标水平均明显升高(P<0.05),而IL-10水平显著下降(P<0.05)。随着IMT值增加,T2DM患者血清中IL-6、血糖、血脂及其他指标水平明显升高,而IL-10水平显著下降,同时组间比较差异有统计学意义(P<0.05)。血清中IL-10水平与其他检测指标水平呈负相关(P<0.05)。IL-6、同型半胱氨酸(Hcy)及血尿酸(UA)是导致T2DM患者动脉粥样硬化形成的危险因素,而IL-10是保护因素。结论 T2DM患者血清中IL-10水平与颈动脉粥样硬化的发生及发展密切相关,为临床治疗提供了新的靶点。

Objective To investigate the expression of IL-10 in serum of patients with type 2 diabetic mellitus（T2 DM）and its relationship with carotid atherosclerosis.Methods Totally 168 cases of T2 DM patients treated in our hospital from May 2013 to December 2016 were retrospectively analyzed.According to the IMT value,the patients were divided into the normal group,the thickening of the group and carotid atherosclerosis plaque formation group.In addition,65 cases of healthy volunteers in our hospital physical examination center at the same period were treated as control group.The levels of serum inflammation index,blood glucose,blood lipid and other indicators of all subjects were compared,at the same time,the correlation between IL-10 and other detection index was analyzed.Additionally,the risk factors of T2 DM patients with carotid atherosclerosis were analyzed.Results Compared with the control group,the levels of IL-6,blood glucose,blood lipid and other indicators in T2 DM patients increased significantly（P〈0.05）,while the level of IL-10 decreased significantly（P〈0.05）;with the increase of IMT,the levels of IL-6,blood glucose,blood lipid and other indicators in T2 DM patients increased significantly,but the level of IL-10 decreased significantly,meanwhile the differences between the groups were statistically significant（P〈0.05）.Compared with normal group,the levels of IL-6,blood glucose,blood lipid and other indicators of patients in thickening group and plaque group significantly elevated,but the level of IL-10 decreased significantly;the levels of IL-6,blood glucose,blood lipid and other indicators of patients in plaque group were obviously higher than those of thickening group,and IL-10 level was significantly lower than thickening group,and the differences were statistically significant（P〈0.05）;the levels of IL-10 in the serum were negatively correlated with blood glucose,blood lipid and other indicators（P〈0.05）;multifactor non-conditional Logistic analysis showed that IL-6,Hcy and UA were the risk factors for atherosclerosis in T2 DM patients,and IL-10 was the protective factor.Conclusion The level of IL-10 of patients with T2 DM is closely related to the occurrence and development of carotid artery atherosclerosis,which provides a new target for clinical treatment.