促甲状腺激素与血糖、血脂水平的相关性研究

A relativity analysis on the incidence of thyroid-stimulating hormone and other biochemical markers of blood glucose and blood fat

目的探讨体检人群促甲状腺激素(TSH)的升高情况及其与血糖、血脂各指标之间的相关性。方法回顾性分析2017年1-5月该院1 070例体检人群TSH、血清总胆固醇(CHOL)、血清三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、血糖(GLU)、糖化血红蛋白(HbA1c)等指标,按性别和年龄进行统计,并分析TSH与血糖、血脂水平的相关性。结果共检出TSH阳性者118例,阳性率为11.03%,其中男性58例,阳性率为9.40%,女性60例,阳性率为13.25%,男女间TSH阳性率差异有统计学意义(χ2=9.819,P<0.05)。TSH与TG、LDL、GLU呈成正相关(r分别为0.006、0.048、0.021,P分别为0.038、0.017、0.045),与HDL呈负相关(r=-0.017,P=0.024),而与CHOL、HbA1c无相关性(P>0.05)。TSH升高组与TSH正常组相比,CHOL水平差异有统计学意义(P<0.05)。结论 TSH的升高已经成为影响人类健康的一个重要因素,应该更加重视。

Objective To investigate the incidence of thyroid-stimulating hormone and its correlation with other biochemical markers of blood glucose and blood fat in health examination population.Methods Physical examination results of 1 070 staff from the First Affiliated Hospital of Hebei North University from January to May 2017,including serum thyroid-stimulating hormone（TSH）,total cholesterol（CHOL）,triglyceride（TG）,and glucose（GLU）,HbA1 cwere sorted,grouped by gender and age,and retrospectively analyzed.Results A total of 118 cases of TSH positive were detected,,the positive rate was 11.03%,of which 58 were male,the positive rate was 9.40% and 60 were women,the positive rate was 13.25%,there was a statistically significant difference in the positive rate of TSH between two groups of male and female（χ~2=9.819,P〈0.05）.TSH was positively related to TG,LDL,and GLU（r=0.006,0.048,0.021;P=0.038,0.017,0.045）,and is negatively related to HDL（r=-0.017,P=0.024）,and had no relation with CHOL and HbA1 c（P〉0.05）.There was a significant difference in the level of CHOL between the TSH group and the normal TSH groups（P〈0.05）.Conclusion TSH has become a major factor affecting human health and should be highly valued.