NF-κB与MTA2在乳腺浸润性导管癌中的表达及相关性研究

Study of the expressions of NF-κB and MTA2 in infiltrating ductal carcinoma of breast and their correlation

目的探讨核转录因子κB(NF-κB)与肿瘤转移相关基因2(MTA2)在乳腺浸润性导管癌组织中的表达及其相关性,并分析其与乳腺浸润性导管癌临床病理参数之间的关系。方法采用实时定量聚合酶链反应检测68例乳腺浸润性导管癌患者的癌组织及配对癌旁正常乳腺组织中NF-κB与MTA2基因的表达情况,并分析其与各临床参数的关系。结果 NF-κB和MTA2在乳腺浸润性导管癌组织中的表达都与年龄、肿瘤大小及组织学分期等指标无关(P>0.05);与淋巴结转移及TNM分期等指标有关(P<0.05)。此外,MTA2在乳腺浸润性导管癌ER阳性患者组织中呈高表达(P<0.05)。乳腺浸润性导管癌组织中NF-κB与MTA2的表达呈正相关(r=0.808,P=0.012)。结论检测NF-κB与MTA2在乳腺浸润性导管癌组织中的表达水平,可为乳腺浸润性导管癌的诊断,侵袭转移程度和预后提供理论依据。

Objective To investigate the expression of NF-κB and MTA2 in infiltrating ductal carcinoma of breast and their correlations to clinicopathologic character.Methods The expressions of and MTA2 in breast cancer and paired adjacent normal breast tissues of 68 breast invasive ductal cancer patients were detected by real-time quantitative PCR method,and their correlations to the clinicopathologic characteristics of breast invasive ductal cancer were analyzed.Results The expressions of NF-κB and MTA2 in breast invasive ductal carcinoma were not related to age,tumor size and histological stage（P〉0.05）,and were positively correlated with lymph node metastasis and TNM stage（P〈0.05）.In addition,MTA2 was highly expressed in the tissues of ER positive breast invasive ductal cancer patients（P〈0.05）.There was a positive correlation between the expression of NF-κB and the expression of MTA2 in breast cancer tissue of the infiltrating ductal carcinoma of breast patients（r=0.808,P=0.012）.Conclusion Measurement of NF-κB and MTA2 from breast invasive ductal carcinoma tissue may provide a theoretical basis for the diagnosis,progression and prognosis of infiltrating ductal carcinoma of breast.