系统性评价红细胞分布宽度在缺铁性贫血诊断中的价值

Systematic evaluation on the diagnostic role of red blood cell distribution width in iron deficiency anemia

目的探讨红细胞分布宽度(RDW)在缺铁性贫血(IDA)中的诊断意义。方法系统检索Cochrane Library、Pubmed和Embase数据库文献,应用Meta-DiSc1.4软件对纳入研究进行综合定量评价,并绘制综合受试者工作特征(SROC)曲线。结果筛选出研究文献得到铁蛋白<10μg/L且研究人群为IDA与β地中海贫血时,共4篇文献符合纳入标准,异质性检验未发现异质性。将RDW>14%作为诊断临界值,Meta分析显示RDW诊断IDA的灵敏度、特异度的汇总值分别为0.92[95%CI(0.88,0.94)]、0.41[95%CI(0.35,0.47)],曲线下面积(AUC)为0.87。结论 RDW诊断IDA的灵敏度较高,具有良好的诊断价值。

Objective To investigate the value of red blood cell distribution width（RDW）in the diagnosis of Iron Deficiency Anemia（IDA）.Methods Most relevant studies,which were retrieved from the Medline,Embase,and the Cochrane Library were identified according to the inclusion and exclusion criteria and data were extracted.Statistical analyses were performed by employing Meta-DiSc 1.4 software.Meta-analysis of the reported accuracy of each study was performed and summary receiver operating characteristic（SROC）curve was drawn.Results Four studies met the inclusion criteria for the analysis.Heterogeneity test did not find significant heterogeneity among included studies.RDW〉14% was taken as the diagnostic critical value,the sensitivity was 0.92[95%CI（0.88,0.94）],the specificity was 0.41[95%CI（0.35,0.47）]and the AUC of SROC was 0.87.Conclusion RDW is sensitive and has good value in the diagnosis of IDA.