卵黄抗体的结构与功能其在人及动物疾病中应用进展

Advances in structure,function and application of egg yolk antibody in human and animal diseases

鸡卵黄免疫球蛋白(IgY)又称卵黄抗体,是禽类受特定抗原刺激后分泌的特异性抗体。因具有耐热、耐酸和抗蛋白酶降解等特性,早期开发产品作为食品或食品添加剂应用受到重视,其产品开发在食品安全、生态农业方面有重要社会效益和经济效益,产品由于含针对某病原生物特异性抗体,可抵抗病原生物的感染,因而在动物及人类疾病的防治方面有开发应用价值,在人类健康保健也有十分重要的应用前景。本文就动物和人类抗病毒、抗细菌、抗寄生虫、抗肿瘤等相关的IgY生物制剂产品研发及应用进行综述。

Egg yolk immunoglobulin(IgY),also called egg yolk antibody,is a specific antibody secreted by birds after stimulation with certain antigens.For that it exhibits good resistance to heat,acid and proteinase-mediated degradation,its early-stage products were developed as food or food additives,and they have gained great social and economic benefits in both food safety and ecological agriculture fields.Due to the specific antibodies contained in these products,the products can help to resist pathogen infection.Therefore egg yolk antibody shows great value for development and application in the prevention and treatment of animal and human diseases,and also shows great potential in human health care area.This review focuses on the development and applications of IgY biologics related with antiviral,antibacterial,antiparasitic and antitumor activities.