摘要
富亮氨酸胶质瘤失活1(leucine-rich glioma inactivated 1,LGi1)蛋白抗体相关脑炎是一种由LGi1抗体参与致病的新型自身免疫性脑炎,主要表现为认知障碍、癫痫、面臂肌张力障碍发作(faciobrachial dystonic seizure,FBDS)和顽固性低钠,其中FBDS是其特征性表现。与传统副肿瘤性自身免疫性脑炎不同,该病因其很少伴有肿瘤,经免疫调节治疗后可获得较好的预后。
Leucine-rich glioma inactivated 1（LGi1） protein antibody-associated encephalitis is a new type of autoimmune encephalitis, characterized by cognitive impairment and epilepsy and faciobrachial dystonic seizures（FBDS） and intractable hyponatremia. Unlike traditional adenomatous autoimmune encephalitis, it is usually not tumourassociated, and its prognosis is better after immunomodulatory therapy.
出处
《临床与病理杂志》
2018年第1期198-204,共7页
Journal of Clinical and Pathological Research
关键词
富亮氨酸胶质瘤失活1蛋白
面臂肌张力障碍发作
顽固性低钠
治疗
预后
leucine-rich glioma inactivated 1 protein
faciobrachial dystonic seizures
intractable hyponatremia
treatment
prognosis
