血小板和中性粒细胞与淋巴细胞比值辅助诊断克罗恩病的价值评价

Diagnostic value of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in Crohn's disease

目的回顾性分析克罗恩病(Crohn's disease,CD)患者和健康对照者血小板/淋巴细胞比值(platelet-to-lymphocyte ratio,PLR)和中性粒细胞/淋巴细胞比值(neutrophilto-lymphocyte ratio,NLR)结果,评价二者在CD的诊断价值.方法纳入60例CD患者和60例健康对照,抽取EDTA抗凝静脉血做血常规检测,分别得到中性粒细胞计数绝对值、淋巴细胞计数绝对值和血小板计数值,经计算得出PLR和NLR.统计学分析和绘制受试者工作曲线(receiver operator characteristic curve,ROC曲线),得出灵敏度(sensitivity,Sen)和特异度(specificity,Spe)和cut-off值.结果与健康对照组相比,PLR和NLR在CD患者中高表达,分别为(181±45.12 vs 86±32.78和3.07±1.02 vs 2.52±1.14),差异有统计学意义(P<0.05),PLR和NLR诊断CD病的ROC曲线下面积分别为0.764和0.828;对应的Sen、Spe和cut-off值分别为:PLR(Sen:76.21%,Spe:84.53%,cut-off值:133.12);NLR(Sen:69.16%,Spe:76.24%,cut-off值:2.85).结论 PLR和NLR辅助诊断CD具有潜在的诊断价值,有望成为廉价、快速的诊断标志.

AIM To investigate the diagnostic efficacy of platelet-to- lymphocyte ratio （PLR） and neutrophil-to-lymphocyte ratio （NLR） in patients with Crohn＇s disease （CD）. EDTA anticoagulant venous blood was collected from CD patients （n = 60） and healthy controls （n = 60）, and routine blood test was performed to obtain the neutrophilic granulocyte count, lymphocyte count, and platelet count. Then, the PLR and NLR were calculated. The sensitivity （Sen）, specificity （Spe）, and cut-off values were calculated by receiver operator characteristic （ROC） curve analysis. RESULTS CD patients had significantly higher PLR （181 ± 45.12 vs 86 ± 32.78） and NLR （3.07 ± 1.02 vs 2.52 ± 1.14） than healthy controls （P 〈 0.05）. The cut-off values for PLR and NLR were 133.12 （Sen： 76.21%; Spe： 84.53%） and 2.85 （Sen： 69.16%; Spe： 76.24%）, respectively, and the areas under the ROC curves for PLR and NLR were 0.764 and 0.828, respectively. CONCLUSION PLR and NLR might be effective and low-cost biomarkers for distinguishing CD patients from healthy controls.