套细胞淋巴瘤迟发性结直肠脑回样浸润1例并文献复习

Mantle cell lymphoma with late onset gyrus-like colorectal infiltration: A rare case and literature review

套细胞淋巴瘤(mantle cell lymphoma,MCL)是一类以染色体t(11;14)(q13;q32)易位和cyclin D1过度表达为特征的非霍奇金淋巴瘤亚型.MCL以老年男性多见,大多数患者在发现时已处于晚期,常伴淋巴结外浸润,尤其以胃肠道浸润常见.多发性淋巴瘤性息肉病是MCL浸润胃肠道的典型表现,浸润部位以结肠最常见.本文报道1例53岁的老年女性MCL患者,诊断为经典型MCL两年,予以6周期的联合化疗取得完全缓解后,出现迟发性结直肠浸润,临床表现为间歇性血便.内镜表现为较少见的黏膜皱襞脑回样增厚,伴糜烂、出血和浅小溃疡.活检组织免疫组化染色显示:淋巴样浸润的结肠黏膜中cyclin D1、CD5、CD19、CD20、CD21、CD43、CD79a、Bcl-2、PAX-5和SOX11(分散)均为阳性,而CD2、CD3、CD7、CD10、CD23、Bcl-6、c-myc和Mum-1均为阴性.增殖指数Ki-67约为15%.

Mantle cell lymphoma （MCL）, characterized by t （11; 14） （q13; q32） translocation and cyclin D1 overexpression, is still a challenging subtype of non-Hodgkin＇s lymphoma. The majority of MCL cases are discovered in male elderly people and in advanced stages with extranodal infiltration especially the gastrointestinal tract. Multiple lymphomatous polyposis is a typical manifestation of MCL infiltrating the gastrointestinal tract, and the colon is the most commonly involved site. In this paper, we report a case of MCL with late onset colorectal infiltration in a 53-year-old female patient presenting with gyrus-like thickened mucosal folds instead of multiple polyps as revealed by colonoscopic examination. Remarkably, the patient developed colorectal infiltration presenting with intermittent bloody stool after being diagnosed with classical MCL for two years and treated with several cycles of combined chemotherapy. Immunohistochemical staining showed that the lymphoid infiltrate in the colorectal mucosa was positive for cyclin D1, CD5, CD19, CD20, CD21, CD43, CD79a, Bcl-2, PAX-5, and SOX11 （scattered）, but negative for CD2, CD3, CD7, CD10, CD23, Bcl-6, c-myc, and Mum-1. The Ki-67 proliferation index was around 15%.