脑性瘫痪胼胝体面积与神经运动发育的相关性研究

Research on the correlation between corpus callosum area size and the neuromotor development of cerebral palsy children

目的探讨脑性瘫痪(CP)患儿胼胝体面积与神经运动发育之间的关系。方法选取脑性瘫痪患儿63例作为研究组,正常儿童60例作为对照组,应用《0~6岁儿童神经心理发育量表》评价脑性瘫痪患儿神经运动发育。对受试儿童进行头颅MRI检查,正中矢状位测量胼胝体总面积及分区面积,分析胼胝体面积与神经运动发育之间的关系。结果研究组胼胝体总面积及分区面积小于对照组,差异具有统计学意义;研究组胼胝体总面积与神经运动发育评分存在正相关性,其中粗大运动及适应能力相关明显。结论脑性瘫痪患儿胼胝体的发育受影响,患儿临床症状越重,胼胝体面积越小,经头颅MRI对其检测可评估脑性瘫痪病情的轻重及治疗效果。

Objective To explore the correlation between the area size of corpus callosum and the development of nerve movement in children with cerebral palsy （CP）. Methods 63 patients with CP were selected as the study group, and 60 cases of normal children were treated as control group. Development of nerve movement was evalua- ted by the neuropsychological development scale of 0 ~ 6 years old children. The total and partition area size of cor- pus callosum were measured by MRI, and analyzed the correlation between the area of corpus callosum and the de- velopment of nerve movement. Results The total and partition area size of corpus callosum in the study group were less than those in control group, and the difference was statistically significant. There was a positive correlation be- tween the total area of the corpus callosum and the neurological motor development score. The coarse motion and the adaptability were correlated significantly. Conclusion The development of CP area might be associated with cerebral palsy. The more severe clinical symptoms in children, the smaller the area of the corpus callosum, the head MRI can assess the severity of cerebral palsy and treatment effect.