病毒诱导气道黏液高分泌机制

Mechanism of virus-induced airway mucus hypersecretion

气道黏液高分泌是慢性呼吸系统疾病重要特征。病毒感染是气道黏液高分泌的常见诱发因素。认识病毒感染与气道黏液高分泌的关系及机制,对防止和减轻气道黏液高分泌,降低慢性呼吸系统疾病的病死率有重要意义。黏蛋白(mucin,MUC)MUC5AC表达增加是气道黏液高分泌的主要病理基础,针对常见呼吸道病毒感染引起的气道黏蛋白MUC5AC分泌的信号传导通路进行讨论很有必要。

Airway mucus hypersecretion is an important fea- ture of chronic respiratory diseases. Viral infection is a com- mon factor inducing airway mucus hypersecretion. Understand- ing the relationship between the viral infection and airway mu- cus hypersecretion and mechanism is very important to pre- venting and reducing airway mucus hypersecretion, decreasing the mortality of chronic respiratory diseases. The increase of MUC5AC expression is the major pathological basis of airway mucus hypersecretion, so it is necessary to discuss the signal transduction pathway of MUC5AC secretion caused by com- mon respiratory virus infection.