抗病毒治疗对慢性丙型肝炎肝纤维化和肝硬化的影响

Effectiveness and safety of direct-acting anfiviral agents for treatment of patients with chronic hepatitis C virus infection

丙型肝炎是全球范围内导致肝脏疾病的主要原因之一。而慢性丙型肝炎会造成肝纤维化及肝硬化，进而发展至失代偿、肝癌等终末期肝脏疾病。抗病毒治疗能够清除病毒，阻止疾病的进展，从而减少晚期肝病的发生。现旨在讨论抗病毒治疗，包括直接抗病毒药物治疗对慢性丙型肝炎肝纤维化及代偿期和失代偿期肝硬化患者的影响及安全．胜。

Hepatitis C is one of the major causes of liver disease worldwide. Chronic hepatitis C can cause liver fibrosis and cirrhosis leading to end-stage liver disease. Antiviral therapy can clear the virus, stop the progress of the disease, thereby reducing the incidence of advanced liver disease. This article aims to discuss the effects and safety of antiviral treatments, including direct- acting antiviral agents, on patients with chronic hepatitis C with fibrosis and compensated and decompensated liver cirrhosis.