吉兰-巴雷综合征的研究进展

The research progress of Guillain-Barré syndrome

吉兰-巴雷综合征(GBS)是一种自身免疫介导的周围神经病,以四肢瘫痪、腱反射消失和脑脊液蛋白-细胞分离为特征。因其可导致呼吸麻痹而成为神经科常见的急危重症之一。GBS的确切病因未明,空肠弯曲菌可能与发病有关,目前认为分子模拟学说是可能的最主要发病机制之一。呼吸道管理是改善呼吸肌麻痹患者的一般情况和改善预后的重要措施。近年来,有不少学者对传统免疫治疗进行了探索和研究,同时也发现了一些新的治疗方法。本文将对近年来GBS的最新研究进展进行综述。

Guillain-Barre syndrome is a peripheral neuropathy mediated by autoimmune,it＇s characterized by paralysis of limbs,disappearance of tendon reflex and separation of protein and cell in eerehrospinal fluid.Because of the result of respiratory paralysis,it is one of the most common acute and severe neurological diseases.The exact etiology of GBS is unknown,Campylobacter jejuni may be related to it,now that the molecular mimicry theory is one of the probably most important pathogenesis.Respiratory management is an important measure to improve the general condition and improve prognosis with respiratory muscle paralysis.In recent years,many scholars have explored and studied the traditional immunotherapy,and some new treatment methods are found at the same time.In this paper,the newest research progress of GBS in recent years are reviewed.