乳腺弥漫大B细胞淋巴瘤9例临床病理特征分析

Clinicopathological features of diffuse large B cell lymphoma of the breast for a report of 9 cases

目的探讨乳腺弥漫大B细胞淋巴瘤(PBDLBCL)的临床病理特征、鉴别诊断及预后。方法回顾性分析2013年3月~2017年8月我院收治的9例乳腺弥漫大B细胞淋巴瘤的临床病理特征、免疫表型,并复习文献。结果 9例乳腺弥漫大B细胞淋巴瘤均为女性,年龄22~80岁,中位年龄52岁;5例为右侧,3例为左侧,1例为双侧。8例确诊为原发,1例为继发。免疫表型:9例乳腺弥漫大B细胞淋巴瘤LCA、CD20、CD79a均阳性表达,CD3、CD5、CK均阴性;Ki-67指数70%~95%,中位数90%。结论乳腺淋巴瘤少见,患者多为女性,好发于单侧乳腺,原发性多见,病理类型主要为弥漫大B细胞型。病理光镜及免疫组化结果有助于诊断及鉴别诊断。

Objective To investigate the clinicopathological features,differential diagnosis and prognosis of diffuse large B cell lymphoma of the breast （PBDLBCL）.Methods 9 cases of patients with diffuse large B cell lymphoma of breast treated in our hospital from March 2013 to August 2017 were selected,and the elinicopathological features and immunophenotype were analyzed retrospectively.The literatures were reviewed.Results 9 cases of diffuse large B cell lymphoma of the breast were female,aged 22-80 years,median age of 52 years.5 cases were right,3 cases were left and 1 cases were bilateral.8 cases were diagnosed as primary and 1 were seeondary.lmmunophenotype：9 cases of diffuse large B cell lymphoma of breast were positive expression of LCA,CD20 and CD79a,CD3,CD5 and CK were negative,Ki-67 index was 70%-95%,median 90%.Conclusion Breast lymphoma is rare,and most of the patients are female.h is very common in unilateral mammary gland.The main pathological type is diffuse large B cell type.Pathological,light and immunohistochemical findings are helpful in the diagnosis and differential diagnosis.