麻杏石甘汤加减治疗31例慢性阻塞性肺疾病急性加重期的疗效及对炎症因子的影响

Efficacy of Maxing Shigan decoction on 31 cases of patients with acute exacerbation of chronic obstructive pulmonary disease and its effects on inflammatory factors

目的:比较麻杏石甘汤加减与常规西药治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床疗效及对炎症因子的影响。方法:选择61例AECOPD患者随机分为观察组(31例,常规西医及麻杏石甘汤加减治疗)和对照组(30例,常规西医治疗)。比较治疗前和治疗后2周两组中医症候积分、肺功能及血清IL-8、TNF-a水平。结果:治疗前,两组上述指标的差异无统计学意义(P>0.05);治疗后,两组中医症候积分、血清IL-8、TNF-a水平均低于治疗前(P<0.05),且观察组低于对照组(P<0.05);而FVC、FEV——1/FVC(%)及PEF均高于治疗前(P<0.05),且观察组高于对照组(P<0.05)。结论:麻杏石甘汤加减治疗AECOPD可缓解临床症状,改善肺功能,降低血清炎症因子IL-8、TNF-a水平。

Objective： To compare the efficacy of Maxing Shigan decoction on acute exacerbation of chronic obstructive pulmonary disease（AECOPD） and its effects on inflammatory factors. Methods： Sixty-one cases of AECOPD patients were selected and divided into an observation group（31 cases, treated with both routine western medical therapy and Maxing Shigan decoction） and a control group（30 cases, treated only with routine western medical therapy） randomly. The TCM score, pulmonary function, IL-8 and TNF-α levels were compared before treatment and 2 weeks after. Results： There were no significant differences between the two groups in the indexes mentioned above before treatment（P〉0.05）. The TCM score, IL-8 and TNF-α levels were decreased while pulmonary function and PEF level were improved, and furthermore these indexes in the observation group were all much better than those in the control group after treatment（P〈0.05）. Conclusion： Maxing Shigan decoction can relieve clinical symptoms, improve pulmonary function and reduce IL-8 and TNF-α levels when is combined with routine western medical therapy.