肠道微生态失衡为骨质疏松症发病的易感因素

The imbalance of gut microecology may be a susceptible factor of osteoporosis

本文通过综述人体肠道菌群和骨代谢的相关性研究,从衰老与胃肠道功能不足是老年性骨质疏松的危险因素、炎症性肠病是并发骨质疏松的危险因素、糖皮质激素是IBD诱发骨质疏松的重要因素、肠道菌群失调是绝经后骨质疏松发生的关键因素等方面探讨了肠道微生态失衡与骨质疏松发生发展的相关性,并从肠道微生态出发对老年性骨质疏松的危险因素和绝经后骨质疏松发生的关键因素做了深入探讨,通过综述国内外实验和临床研究,认为肠道微生态失衡是骨质疏松症发病的易感因素。

In this paper,the relationship between the imbalance of gut flora and osteoporosis is explored by reviewing the correlation between gut flora and bone metabolism in the human body,the aging and gastrointestinal dysfunction in senile osteoporosis,the inflammatory bowel disease,the glucocorticoid in IBD-induced osteoporosis,and the imbalance of gut flora in postmenopausal osteoporosis. The risk factors of senile osteoporosis and the key factors of postmenopausal osteoporosis are deeply based on intestinal microecology. According to the review of domestic and international experimental and clinical research,we believe that the intestinal microecological imbalance is the predisposing factor of osteoporosis.