神经肽Y在骨微损伤修复机制中的作用

The role of neuropeptide Y in the repair mechanism of bone microdamage

骨微损伤是骨疲劳所致骨显微结构改变的结果,微损伤的不断积累最终可引发骨折,研究骨微损伤的形成及其修复机制对阐明骨质疏松的发病机制有重要意义。大量研究发现神经肽Y(neuropeptide Y,NPY)在骨微损伤修复过程中起到重要的作用,本文综述了NPY在骨微损伤修复机制中的作用,为骨质疏松性骨折的早期诊断与治疗提供一定的参考。

Bone microdamage is the microstructural consequence of fatigue in bone,and the accumulation of microdamage can lead to fractures. The research on formation and repair mechanism of bone microdamage is important for clarifying the pathogenesis of osteoporotic fracture. Many research has found that neuropeptide Y（NPY） plays an important role in bone remodeling. This review summarizes the role of NPY in repair mechanism of bone microdamage,hoping to make a useful reference for early diagnoses and prevention of the osteoporotic fracture.