(S)-联萘酚钛体系催化3-噻吩铝试剂对酮的不对称加成反应（英文）

Asymmetric Addition of 3-Thienyl Aluminum to Ketones Catalyzed by the Simple Titanium Catalytic System of(S)-1,1'-Binaphthol

含噻吩基团的的手性芳香醇是自然界重要的活性物质,其基本结构单元广泛地存在于生物活性物质和医药中.报道了(S)-联萘酚和Ti(OiPr)_4催化3-噻吩基铝试剂对酮的不对称加成反应,以较高的产率和优异的立体选择性(高达91%ee)得到相应的含有3-噻吩基乙醇.该催化体系具有广泛的适应性,能够适合含有吸电子和供电子基团的各种酮的不对称加成,得到相应的3-噻吩基乙醇.

The optically active diaryl alcohols bearing thienyl group are well-known for their biological activity as well as key substructure in bioactive compounds and pharmaceuticals. The asymmetric addition of 3-thienyl aluminum to ketones afforded the optically active 3-thienyl arylethanols in good yields with high enantioselectivities of up to 91% ee employing the simple titanium catalytic system of（S）-1,1＇-binaphthol. The catalytic system could also suit for various ketones bearing an electron-donating or electron-withdrawing groups to afford the corresponding diarylethanols containing substituted 3-thienyl groups.