耐碳青霉烯类肺炎克雷伯菌的分子流行特点及耐药机制

Molecular epidemiological characteristics and drug resistance mechanisms of carbapenem-resistant Klebsiella pneumoniae

目的目前,耐碳青霉烯类肺炎克雷伯菌(CRKP)在全球很多地区医院中的分离率越来越高,引起WHO及国内外同行高度关注,在抗菌药物的选择性压力下,碳青霉烯酶耐药基因可位于不同的移动元件,在相同及不同种属细菌之间播散,给临床感染防控带来极大挑战,笔者拟通过对CRKP分子流行病学特点、碳青霉烯酶基因及整合子介导的耐药机制研究进展进行综述,为CRKP感染的预防和控制提供依据。

OBJECTIVE The isolation rate of carbapenem-resistant Klebsiella pneumoniae（CRKP）is increasingly high in hospitals around the globe at present,which attracts considerable attention by the WHO as well as the peers at home and abroad.The carbapenemase resistance genes may locate in different mobile elements under the selection pressure of antibiotics and disseminate among the same and different genera and species of bacteria,which makes the clinical prevention and control tough.The authors conduct the review by introducing the epidemiological characteristics of CRKP and carbapenemase genes as well as integron-medicated drug resistance mechanisms so as to provide guidance for prevention and control of the CRKP infection.