老年肺炎患者血浆超氧化物歧化酶水平与严重程度及脓毒症的相关性

Correlation of Plasma Superoxide Dismutase Levels with the Severity and Incidence of Sepsis in Elderly Patients with Pneumonia

目的:探讨老年肺炎患者血浆超氧化物歧化酶(SOD)水平与病情严重程度及发生脓毒症的相关性。方法:将我院呼吸内科收治的60例老年肺炎患者(肺炎组)根据入院时肺炎严重指数(PSI)分为低危组(n=25)、中危组(n=24)、高危组(n=11),并选择同期非肺炎患者50例作为对照组,同时根据患者是否并发脓毒症分为脓毒症组(n=21)、非脓毒症组(n=39)。比较各组患者APACHE III评分、血浆PCT及SOD水平,并分析上述指标之间的相关性。结果:肺炎组患者APACHE III评分、血浆PCT均较对照组显著升高,而血浆SOD显著降低,且随着病情的加重,APACHE III评分、血浆PCT依次增加,血浆SOD依次降低(P<0.05)。与非脓毒症组比较,脓毒症组APACHE III评分、血浆PCT均显著升高,血浆SOD显著降低(P<0.05)。老年肺炎患者血浆SOD水平与APACHE III评分、血浆PCT均呈线性负相关(P<0.05)。结论:老年肺炎患者的血浆SOD水平明显降低,且随着病情的加重及合并脓毒症,SOD水平下降程度更为显著。血浆SOD可用于辅助评估老年肺炎患者的病情及脓毒症的发生风险。

Objective： To explore the correlation of plasma superoxide dismutase levels with severity and sepsis in elderly patients with pneumonia. Methods： According to the pneumonia severity index（PSI） on admission, 60 elderly pneumonia patients（pneumonia group） who were admitted in respiratory Medicine of our hospital were divided into three groups, including low-risk group（n=25）,moderate-risk group（n=24）, high-risk groups（n=11）, and compared with 50 non pneumonia patients in the control group. All the patients were also divided into sepsis group（n=21） and non sepsis group（n=39）. The plasma PCT, SOD levels and APACHE Ⅲ score were detected and compared among three groups, and the correlation among those indicator were analyzed. Results： The APACHE Ⅲ score,plasma PCT level of pneumonia group were significantly higher, and plasma SOD was significantly lower than those of the control group（P〈0.05）. As the illness was aggravating, the APACHE Ⅲ score, plasma PCT level were also increased, the plasma SOD reduced（P〈0.05）. Compared with non sepsis group, the APACHE Ⅲ score, plasma PCT level of sepsis group were significantly increased, the plasma SOD level was significantly decreased（P〈0.05）. The plasma SOD level in elderly patients with pneumonia was negatively correlated with the APACHE Ⅲ score and plasma PCT level（P〈0.05）. Conclusions： The level of plasma SOD in elderly patients with pneumonia was decreased, which was correlated with the severity and incidence of sepsis. The plasma SOD level could assess the progression of disease and the occurrence risk of sepsis in elderly patients with pneumonia.