瑞格列奈联合甘精胰岛素对2型糖尿病患者血糖及胰岛β细胞功能的影响

Effect of Repaglinide Combined with Insulin Glargine on Blood Glucose and Islet β Cell Function in Patients with Type 2 Diabetes Mellitus

目的:探究瑞格列奈联合甘精胰岛素对2型糖尿病(T2DM)患者血糖及胰岛β细胞功能的影响。结果:选择我院2016年1月至2017年1月收治的130例2型糖尿病患者,采用随机法将患者分为两组,各65例。对照组患者给予甘精胰岛素治疗,观察组在此基础上加用瑞格列奈治疗,比较两组血糖水平、胰岛β细胞功能及安全性。结果:治疗后两组临床治疗效果、FPG、2h PG、FCP及PCP等指标相比,观察组均明显优于对照组(P<0.05);两组FPG、2h PG、FCP及PCP等指标相比,治疗后均优于治疗前(P<0.05);不良反应发生率,观察组为7.69%,对照组为4.62%,两组比较差异无统计学意义(χ2=0.133,P>0.05)。结论:瑞格列奈联合甘精胰岛素能提高2型糖尿病患者临床治疗效果,有效改善血糖水平和胰岛β细胞功能,且不良反应率低,用药安全性高。

Objective： To investigate the effect of repaglinide combined with insulin glargine on blood glucose and islet β cell function in patients with type 2 diabetes mellitus（T2 DM）. Methods： 130 T2 DM patients from January 2016 to January 2017 were selected from Xixian County People＇s Hospital of Henan province,and they were divided into two groups by random number table,65 cases in each group. Control group was given insulin glargine,while observation group was treated with repaglinide based on control group. The blood glucose level,islet β cell function and safety were compared between the two groups. Results： After treatment,the clinical effect,FPG,2 h PG,FCP,PCP in observation group were better than those in control group（P 〈0. 05）. After treatment,the FPG,2 h PG,FCP,PCP in two groups were better than those before treatment（P 〈0. 05）. The incidence of adverse reactions was 7. 69% in the observation group and 4. 62% in the control group,and there was no significant difference between the two groups（χ2= 0. 133,P〉 0. 05）. Conclusion：Repaglinide combined with insulin glargine in treatment of T2 DM can increase clinical effects,improve blood glucose and islet β cell function,have low incidence of adverse reactions and high drug safety.