辛伐他汀中效治疗致横纹肌溶解并肝酶增高1例

A Case of Rhabdomyolysis and Elevated Liver Enzyme Induced by Simvastatin Intermediate-efficacy Treatment

结合文献分析我院发生的辛伐他汀中效治疗致横纹肌溶解并肝酶增高病例1例。辛伐他汀中效治疗致横纹肌溶解并肝酶增高的具体发生机制仍不清楚,考虑与抑制CYP3A4酶活性的药物联合应用,会增加用药风险。辛伐他汀中效治疗致横纹肌溶解并肝酶增高是严重的、罕见的不良反应,应引起医疗机构的重视,做好不良反应监测,做到安全有效用药。

Make a comprehensive analysis about the rhabdomyolysis and elevated liver enzyme induced by simvastatin intermediateefficacy treatment in our hospital,combined with the existing similar reports. The specific mechanism of simvastatin intermediate-efficacy treatment induce rhabdomyolysis and elevated liver enzymes is still unclear. But combination the drug of inhibition of CYP3A4 activity can increase the risk. The incidence of simvastatin intermediate-efficacy treatment induce rhabdomyolysis and elevated liver enzymes are serious and rare adverse reactions,should be caused the attention of medical institutions,completes the adverse reaction monitoring,achieves safe and effective use of drugs.