摘要
目的探讨血清细胞角质蛋白19片段CYFRA21-1、糖类抗原19-9(CA19-9)、鳞状细胞癌抗原(SCCAg)单独及联合检测在食管癌诊断中的价值。方法选取100例食管癌患者(观察组)和50例健康志愿者(对照组),检测两组受试者的血清CYFRA21-1、CA19-9和SCCAg水平,并按照临床分期对观察组患者进行亚组分析,采用受试者工作曲线(ROC)分析CYFRA21-1、CA19-9和SCCAg检测在食管癌诊断中的价值。结果观察组患者的血清CYFRA21-1、CA19-9和SCCAg水平均明显高于对照组,Ⅰ~Ⅱ期患者的血清CYFRA21-1、CA19-9和SCCAg水平均明显低于Ⅲ~Ⅳ期,差异均有统计学意义(P﹤0.01);血清CYFRA21-1、CA19-9、SCCAg三者联合检测诊断食管癌的灵敏度为82.26%,特异度为91.33%,阳性预测值为86.14%,阴性预测值为89.57%,AUC值为0.864,均高于其中任一项指标单独检测,差异均有统计学意义(P﹤0.05)。结论血清CYFRA21-1、CA19-9、SCCAg三者联合检测可以提高食管癌诊断的灵敏度和特异度。
Objective To investigate the value of serum cytokeratin 19 fragment（CYFRA21-1）, carbohydrate antigen 19-9（CA19-9） and squamous cell carcinoma antigen（SCCAg） in the diagnosis of esophageal cancer. Method 100 cases of esophageal cancer（study group） and 50 healthy subjects（control group） were recruited in the study, the serum levels of CYFRA21-1, CA19-9 and SCCAg in these patients were detected. Subgroups analysis was performed in study group by clinical staging, and the diagnostic value of CYFRA21-1, CA19-9 and SCCAg in detecting esophageal cancer was analyzed by receiver operating characteristic curve（ROC）. Result The serum levels of CYFRA21-1, CA19-9 and SCCAg in study group were significantly higher than those in control group, and those were significantly lower in patients with stage Ⅰ-Ⅱ disease than those with stage Ⅲ and Ⅳ disease, indicating statistically significant difference（P〈0.01）; the sensitivity of serum CYFRA21-1, CA19-9 and SCCAg in the diagnosis of esophageal cancer was 82.26%, and specificity was 91.33%, with positive predictive value being 86.14%, and negative predictive value being 89.57%, and AUC value was 0.864, the combined detection was superior to each measure utilized alone, the difference was significantly significant（P〈0.05）. Conclusion The combined detection of serum CYFRA21-1, CA19-9, and SCCAg can significantly improve the diagnostic sensitivity and specificity in detecting the esophageal cancer.
出处
《癌症进展》
2018年第2期186-188,共3页
Oncology Progress
