注射用盐酸氨溴索治疗社区获得性肺炎的疗效观察

Observation on efficacy of ambroxol hydrochloride for injection in the treatment of communityacquired pneumonia

目的观察注射用盐酸氨溴索治疗社区获得性肺炎的临床疗效。方法 96例社区获得性肺炎患者,随机分为对照组和观察组,各48例。对照组患者采用常规方法治疗,观察组患者在对照组基础上加用注射用盐酸氨溴索治疗。治疗10 d后观察两组患者的临床疗效及不良反应发生情况。结果对照组治疗显效21例,有效19例,无效8例,治疗总有效率为83.33%;观察组治疗显效25例,有效21例,无效2例,治疗总有效率为95.83%;观察组治疗总有效率明显高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论采用注射用盐酸氨溴索治疗社区获得性肺炎能明显提高临床疗效,且未明显增加药物不良反应。

Objective To observe the clinical efficacy of ambroxol hydrochloride for injection in the treatment of community-acquired pneumonia. Methods A total of 96 patients with community-acquired pneumonia were randomly divided into control group and observation group, with 48 cases in each group. The control group was treated with conventional therapy, and the observation group was treated with ambroxol hydrochloride for injection on the basis of the control group. After 10 d of treatment, observation were made on clinical efficacy and occurrence of adverse reactions between the two groups. Results The control group had 21 excellent cases, 19 effective cases and 8 ineffective cases, with total treatment effective rate as 83.33%, while the observation group had 25 excellent cases, 21 effective cases and 2 ineffective cases, with total treatment effective rate as 95.83%. The observation group had obviously higher total treatment effective rate than the control group, and the difference was statistically significant（P〈0.05）. Both groups had no statistically significant difference in incidence of adverse reactions（P〉0.05）. Conclusion Ambroxol hydrochloride for injection can obviously improve clinical efficacy in treating communityacquired pneumonia without significantly increasing the adverse drug reactions.