细粒棘球绦虫蛋白质组学研究进展

Advances in Echinococcus granulosus Proteomics

随着人类基因组计划(Human genomic project,HGP)的实施和推进,生命科学研究已进入后基因组时代,而蛋白质组学是后基因组时代生命科学研究的热门之一。包虫病作为一种重要的人兽共患病,给人类带来了巨大的健康威胁和经济损失,因此,包虫病的预防、诊断和治疗是人们迫切需要研究的课题,本文就近几年细粒棘球绦虫蛋白质组学研究的进展进行叙述,并对相关的研究方法和手段作出科学的论述,旨在阐述细粒棘球绦虫与宿主在分子水平的相互作用方式,为包虫病的疫苗研发、诊断标志物和诊断药物靶点的筛选提供参考。

With the Human genome project＇s（HGP）implementation and propulsion,life science research has entered a post-genome era.In this era,proteomics has become a hot study of life science.Echinococcosis is a significant health burden for humans in developing world and also lead to substantial economic losses in livestock production around the world.Therefore,the prevention,diagnosis and treatment had been a major issue in parasite research.This paper reviews present advances in the proteomics of Echinococcusgranulosus（E.granulosus）,highlights some means and methods.This will highlight some of the advances that have been made in understanding the host-parasite in E.granulosusinfection,provide the base-data for development of diagnostic methods,new medicine and vaccines for E.granulosus.