早发性卵巢功能不全激素补充治疗

Hormone replacement treatment in women with premature ovarian insufficiency

早发性卵巢功能不全(POI)是指女性40岁之前卵巢活动衰退,对患者健康造成严重不良影响的临床综合征。POI患者更需要激素补充治疗(HRT),并且HRT风险更低,只要没有禁忌证,应积极推荐POI患者使用HRT以缓解症状并降低远期风险。POI患者建议应用系统性HRT,推荐序贯方案。所需雌激素剂量相对更高,孕激素剂量需根据雌激素的剂量相应调整。HRT用药期间应定期检查并评估利弊,建议长期应用,至少持续至正常绝经年龄。

Premature ovarian insufficiency （POI） de- scribes a spectrum of declining ovarian function in women younger than 40 years, which has severe in- fluence on health.In women with POI, hormone re- placement treatment （HRT）is required and with lower risks.HRT is an effective approach to treat the symp- toms of hypoestrogenism and mitigate long-term health risks if there are no contraindieations to treatment. Systemic HRT with cyclic administration is recom- mended.The dose of estrogen in women with POI is higher, and the dose of progesterone is adjusted ac- cording to the dose of estrogen.During treatment evaluation for all women with POI should be done, and the treatment should last at least until the average age of natural menopause.