3D打印工艺参数对组织工程支架微观结构的影响研究

Effect of 3D Printing Parameters on Microstructure of Tissue Engineering Scaffolds

挤出式3D打印是制备组织工程支架的重要技术手段之一.一个性能良好的组织工程支架必须具备小孔隙、高孔隙率的内部微观结构.针对挤出式3D打印支架成形动态过程,建立了打印材料成形过程热-力耦合动力学模型,并通过数值模拟研究了主要打印工艺参数对支架成形的孔隙尺寸、材料重熔特性的影响.结果表明,支架的孔隙尺寸随打印时间间隔和材料粘度的增大而增大,但随基板温度的升高而降低;支架重熔度与孔隙尺寸变化趋势相反;其中材料粘度的变化对成形支架的孔隙尺寸和重熔度的影响最为明显.

Extrusion-based 3D printing is one of the most important techniques for preparing tissue engineer- ing scaffolds. A well-performed tissue engineering scaffold must have an internal microstructure with small pores and high porosity. A thermo-mechanical coupling dynamics model of printing material forming process is established for the scaffold forming dynamic process in extrusion-based 3D printing. The influence of the main parameters in printing process on the pore size and remelting properties of the formed scaffold is studied by numerical simulation. The results show that the pore size of the scaffold increases with both the printing time interval and material viscosity increasing, but with the suhstrate temperature decreasing while the re- sults of the remelting degree of the scaffold is competely opposite; and the change of material viscosity has the most obvious influence on the pore size and remelting degree of the scaffold formed.