摘要
卵巢癌是最致命的妇科恶性肿瘤。虽然上皮性卵巢癌约占人类所有卵巢癌的90%,但该病的病因学了解甚少。促性腺激素释放激素(gonadotropin-releasing hormone,GnRH)是下丘脑-垂体-性腺轴关键的调节器,主要调节脊椎动物的繁殖。研究发现,GnRH已经显示出对卵巢癌细胞有直接的抗增殖作用。GnRH受体是G蛋白偶联受体(G protein–coupled receptor,GPCR)家族的成员。本文主要就GnRH介导的GPCR信号系统与卵巢癌细胞的抗增殖作用之间的关系展开综述。
Ovarian cancer is the most lethal gynecological malignancy. Although epithelial ovarian carcinomas account for approximately 90% of all human ovarian cancers, the etiology of this disease is poorly understood. Gonadotropin-releasing hormone（GnRH） is a key regulator of the hypothalamic-pituitary-gonadal axis, primarily regulating the reproduction of vertebrates. Some studies have found that Gn RH has direct antiproliferative effects on ovarian cancer cells. GnRH receptor is a member of the G protein-coupled receptor（GPCR） family. This article reviews the relationship between GnRH and antiproliferative effects of ovarian cancer cells.
作者
王蓉
贾瑞丹
杨晓慧
李康丽
陈琪
杨丽
陈霏霏
WANG Rong, JIA Ruidan, YANG Xiaohui, LI Kangli, CHEN Qi, YANG Li, CHEN Feifei(Shaanxi Normal University, College of Life Science, Xi＇an 710119, Chin)
出处
《生命的化学》
CAS
CSCD
2018年第1期114-118,共5页
Chemistry of Life
