免疫调控米色脂肪生成的研究进展

Advances in immune regulation of beige adipose tissue

哺乳动物中米色脂肪是一种被新发现的产热脂肪组织,可由白色脂肪转化而成,在机体的糖、脂代谢中起到了重要作用。研究表明,免疫系统跟脂肪代谢息息相关,它可以从多个方面来调控米色脂肪,比如骨髓、嗜酸性粒细胞、2型先天性淋巴细胞(ILC2)、IL-4/IL-13。本文就免疫系统(免疫器官、免疫细胞、免疫因子)对米色脂肪的调控作用加以综述,以期为治疗肥胖及其相关代谢疾病提供新的思路。

The beige adipose tissue in mammals is a newly discovered heat adipose tissue which can be transformed from white fat. It plays an important role in the metabolism of carbohydrate and lipid. Studies have shown that the immune system was closely related to fat metabolism and it could regulate beige fat in many aspects, such as bone marrow, eosinophils, ILC2, IL-4/IL-13. Here we reviewed the induction of beige fat in the immune system including immune organs, immune cells, and immune factors, in order to provide a new way for the treatment of obesity and its related metabolic diseases.