摘要
白细胞介素27(interleukin-27,IL-27)是一种新发现的IL-6/IL-12家族成员,是由p28亚基和EB病毒诱导基因3亚基构成的异源二聚体复合物。它的受体由WSX-1、gp130组成。IL-27主要通过激活Janus激酶信号转导和转录激活因子(Janus kinase signal transduction and transcriptional activator,JAK/STAT)信号转导通路调节Th1、Th2、Th17、Tregs、CD8+T、Tfh等多种T细胞的分泌和活性,以实现抗炎、抗肿瘤等生物学功能。本文就IL-27与各类T细胞的相互作用机制作一综述,以期为临床应用提供参考。
As a new member of IL-6/IL-12 cytokine family, IL-27 is a heterodimeric cytokine composed of the p28 and EBI3. Its receptors are composed of WSX-1 and gp130. IL-27 regulates the secretion and activity of Th1, Th2, Th17, Tregs, CD8＋T, Tfh and other T cells mainly by activating Janus kinase signal transduction and transcriptional activator signal transduction pathway to achieve anti-inflammatory, anti-tumor and other biological functions. We have reviewed the interaction mechanism between il-27 and various T cells, In order to provide reference for clinical application.
作者
王贝
黄娜
WANG Bei, HUANG Na(1Department of Respiratory Medicine, the First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, Chin)
出处
《生命的化学》
CAS
CSCD
2018年第1期144-149,共6页
Chemistry of Life
基金
四川省教育厅项目(17ZA0118)
