高原相关性血小板改变的机制探讨

New insights into mechanisms of high altitude-associated platelet abnormalities

近年来,部队在高原地区执行作战任务和非作战任务的频率日益增加。但高原独特的地理环境会对人体各系统,尤其是心血管系统、呼吸系统和血液系统造成一系列的病理损害,严重影响了官兵的身体健康,也直接影响了部队战斗力的生成和维系。血小板(PLT)是血液中重要的细胞之一,官兵进驻高原后会出现PLT水平和功能的改变,严重者会导致血栓性疾病或PLT减少性紫癜。但是,国内外对高原相关性PLT水平或功能改变的研究少之又少,而且高原环境诱导PLT改变的发生机制仍未完全阐明。因此,深入探讨高原相关性PLT改变的发生机制,对于预防高原PLT相关性疾病、发掘有效的干预措施、改善高原官兵的生活质量有着非常重要的基础和临床指导意义。本研究将结合近年来PLT研究的最新成果,探讨高原相关性PLT改变的可能机制,为高原PLT相关性疾病的预防和治疗提供新思路。

In recent years,combat missions and non-combat missions of the army have been more and more frequent in the highlands.However,the special geographical environment in highlands will cause a series of damage to the human body,especially cardiovascular systems,respiratory system and hematologic systems,which will threaten the health of soldiers and directly affect the combat effectiveness.Platelets（PLT）are important blood cells.Soldiers entering the highlands always occur changes of PLT levels and functions,in which severe cases can lead to thrombotic disease and thrombocytopenic purpura.Nevertheless,the studies about high altitude-associated PLT abnormalities are scarce and the underlying mechanisms are far from elucidated.Therefore,deep investigations into high altitude-associated PLT abnormalities are the essential steps in preventing PLT-associated diseases,searching for effective intervention measures and improving the life quality of soldiers in highlands.In this article,we will summarize the latest research findings and discuss the potential mechanisms underlying high altitude-associated PLT abnormalities.Finally,we expect to provide new insights into the prevention and treatment of high altitude-associated PLT abnormalities.