手足口病多价疫苗研究进展

Research progress on development of multivalent vaccine against hand, foot and mouth disease

手足口病是5岁以下儿童的常见传染病,由多种肠道病毒感染引起,在中国和亚太其他地区出现过多次大规模流行。全球首支手足口病EV71单价灭活疫苗于2015年底在中国上市,缓解了部分疫情,目前尚无手足口病多价疫苗。本文就手足口病多价疫苗及其动物模型的研究进展做一综述。

Hand, foot and mouth disease （HFMD） is a common contagious disease in children under 5 years old, and caused by a variety of different enterovirus infection. There were several large-scale outbreaks of the disease in China and other Asia-Pacific region. The first inactive EV71 vaccine was approved in China in December 2015. The univalent vaccine prevents a part of the epidemics. However, there is no multivalent vaccines for HFMD. This article reviews the progresses in the development of multivalent HFMD vaccines as well as animal models.