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生精通络赞育方治疗特发性弱精子症肾虚瘀阻证57例疗效观察 被引量:13

Clinical Observation on 57 Cases of Idiopathic Asthenospermia with Syndrome of Kidney Deficiency and Blood Stasis Treated with Shengjing Tongluo Zanyu Decoction(生精通络赞育方)
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摘要 目的观察生精通络赞育方治疗特发性弱精子症肾虚瘀阻证的临床疗效及安全性。方法将120例特发性弱精子症患者随机分为治疗组和对照组各60例。治疗组口服生精通络赞育方,每日1剂,分两次口服;对照组口服五子衍宗软胶囊,每日3次,每次1.8 g;清脉通络丸,每日3次,每次10 g。两组均连续治疗12周后评价临床疗效、单项症状疗效。比较两组治疗前后a级、(a+b)级精子活力、精子活动率及精子直线运动速度、中医症状积分。结果治疗组临床疗效总有效率为89.47%(51/57),优于对照组的81.82%(45/55)(P<0.05),且各单项中医症状疗效总有效率均优于对照组(P<0.05)。两组治疗后a级、(a+b)级精子活力,精子活动率,精子直线运动速度,中医症状积分均较治疗前改善,且治疗组均优于对照组(P<0.01)。两组均未发生明显不良反应。结论生精通络赞育方治疗特发性弱精子症肾虚瘀阻证临床疗效确切,能有效改善精子活力及活动率,安全性好。 Objective To observe the clinical efficacy and safety of Shengjing Tongluo Zanyu Decoction in the treatment of idiopathic asthenospermia with syndrome of kidney deficiency and blood stasis. Methods One hundred and twenty patients with idiopathic asthenospermia were randomly divided into treatment group and control group,with 60 cases in each group. Treatment group was given Shengjing Tongluo Zanyu Decoction orally,one dose daily,taking separately in the morning and evening. Control group was given Wuzi Yanzong soft capsule( 五子衍宗软胶囊)orally,1. 8 g each time,three times a day. Control group was also given Qingmai Tongluo pills( 清脉通络丸),10 g each time and three times a day. The clinical efficacy and the curative effect of single symptom were evaluated in the two groups after 12-week continuous treatment. The sperm activity of Grade A and Grade( A + B),sperm motility rate,the speed of sperm linear movement and the symptom score of Chinese medicine were compared between the two groups before and after treatment. Results The total effective rate of treatment group was 89. 47%( 51/57),which was better than that of control group( 81. 82%,45/55)( P〈0. 05),and the total effective rate of each single Chinese medicine symptom in treatment group was better than that in control group( P〈0. 05). After treatment,the sperm activity of Grade A and Grade( A + B),sperm motility rate,the speed of sperm linear movement and the symptom score of Chinese medicine in the two groups were better than those before treatment,and those in treatment group were better than those in control group( P〈0. 01). There was no obvious adverse reaction in both two groups.Conclusion Shengjing Tongluo Zanyu Decoction seems to have accurate curative effect in the treatment of idiopathic asthenospermia with syndrome of kidney deficiency and blood stasis. It could effectively improve the sperm activity and motility rate with good safety.
作者 张华 孙自学 李鹏超 张宸铭 陈建设 张辉 ZHANG Hua, SUN Zixue, LI Pengchao, ZHANG Chenming, CHEN Jianshe, ZHANG Hui(Henan Province Hospital of Chinese Medicine, Zhengzhou, 45000)
机构地区 河南省中医院
出处 《中医杂志》 CSCD 北大核心 2018年第6期490-493,共4页 Journal of Traditional Chinese Medicine
基金 国家自然科学基金(81573981) 国家中医药管理局“十二五”中医药重点学科建设项目(国中医药医政发[2012]2号) 河南省中医临床学科领军人才培育计划 河南中医药大学特色学科建设项目
关键词 特发性弱精子症 肾虚瘀阻证 生精通络赞育方 精子活力 idiopathic asthenospermia Shertgfing Tongluo Zanyu Decoction sperm activity
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