摘要
肿瘤多药耐药(multidrug resistance,MDR)对肿瘤的药物治疗的疗效有严重的影响。多药耐药拥有十分复杂的发生发展的机制。通过讨论自噬与药物抗肿瘤时的相互影响,旨在阐明自噬与肿瘤细胞多药耐药的关系,为今后抗肿瘤药物治疗的临床应用提供新的思路。
Tumor multidrug resistance(MDR) has seriously affected the efficacy of drug therapy on tumors. The occurrence of multidrug resistance has a very complex mechanism. In this paper, we discuss the relationship between autophagy and drug anti-tumor, aiming to elucidate the relationship between autophagy and multidrug resistance in tumor cells, and provide new ideas for the clinical application of anticancer drugs.
作者
赵英迪
刘克辛
ZHAO Yingdi, LIU Kexin(College of Pharmacy, Dalian Medical University, Dalian, Liaoning 116044, Chin)
出处
《药物评价研究》
CAS
2018年第1期5-13,共9页
Drug Evaluation Research
基金
国家自然科学基金项目(81473280)
关键词
肿瘤
自噬
多药耐药
tumor
autophagy multidrug
resistance