转运体介导的药物相互作用对药物吸收的影响及其临床意义

Effects of transporter-mediated drug interactions on drug absorption and its clinical significance

目前,临床实践中使用的大多数药物是经口服给药,必须经过充分和持续地吸收才能达到效果。药物吸收在口服药物治疗疾病中起着先决条件,其中药物转运体在药物的肠道吸收中起主要作用。同时药物的联合应用在临床上越来越普遍,通常通过使用多种药物来达到治疗效果,但联合用药大多会产生一定的药物相互作用,从而影响药物的药动学特点。综述肠道转运体介导的几类药物相互作用对其吸收的影响及临床意义,为临床应用提供参考。

Presently, most of the drugs used in clinical practice are administered orally and must be adequately and continuously absorbed to achieve results. Drug absorption plays a prerequisite for oral drug treatment of diseases in which drug transporters play a major role in the intestinal absorption of the drug. At the same time, the combined use of drugs is becoming more and more common in clinic, usually through the use of a variety of drugs to achieve therapeutic effect, but most of the combination of drugs will produce a certain drug interactions, thus affecting the pharmacokinetics of drugs. This review summarizes the effects of several types of drug interactions mediated by intestinal transporter on its uptake and its clinical significance.