摘要
黏液过度分泌是变应性鼻炎、慢性鼻-鼻窦炎、哮喘、慢性阻塞性肺疾病和囊性纤维化等呼吸道炎性疾病的重要特征。杯状细胞化生、黏液纤毛清除功能障碍是导致鼻腔及呼吸道黏液积聚的重要病理改变。新近研究发现，钙激活氯离子通道（calcium—activated chloride channels，CaCCs）的分子结构跨膜蛋白16A（transmembrane protein 16A，TMEM16A）与黏液分泌调控有关，不仅表现在介导电解质跨上皮转运及水合作用，还参与黏液中黏蛋白5AC的分泌调节。本文介绍TMEM16A在呼吸道黏膜上皮的表达和功能的研究进展。
Mucus hypersecretion is significant feature of respiratory inflammation, such as allergic rhinitis, chronic rhinosinusitis, asthma, chronic obstructive pulmonary disease and cystic fibrosis.The metaplasia of goblet cells and dysfunctional mucociliary clearance are the major pathologic changes of nasal and airway mucus accumulation.Recent research have found that the molecular identity of the calcium-dependent chloride channels,transmembrane protein 16A,related to the secretion of mucus.TMEM16A not only play an important role in electrolyte transepithelial transport and hydration in airway epithelial cells,also involved in secretion regulation of Muc5ac.This paper introduces the research progress of TMEM16A in the expression and function of respiratory mucosal epithelium.
作者
张涛
王向东
张罗
Zhang Tao, Wang Xiangdong, Zhang Luo(Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otolaryngology, Key Laboratory of Otolaryngology Head and Neck Surgery（Capital Medical University）, Ministry of Education, Beijing Key Laboratory of Nasal Diseases, Beijing 100730, China ; Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China)
出处
《国际耳鼻咽喉头颈外科杂志》
2018年第2期67-72,共6页
International Journal of Otolaryngology-Head and Neck Surgery
基金
国家自然科学基金重点国际合作项目（81420108009）,国家自然科学基金重点项目（81630023）,国家自然科学基金面上项目（81570894）,教育部长江学者和创新团队发展计划（IRT13082）,北京市卫生系统高层次卫生技术人才（2009-2-007、2011-3.039、2011-3.043、2014-3-018）,北京市医院管理局使命人才计划（SML20150203）,北京市科技项目统筹课题（Z171100000117002）,北京市自然科学基金（7172054）联合资助
关键词
呼吸道黏膜
杯状细胞
氯通道
钙激活
Respiratory Mucosa
Goblet Cell
chloride channels, calcium-activated
