吹扫捕集-气相色谱-三重四级杆串联质谱法测定生活饮用水中22种挥发性有机物

Determination of 22 volatile organic compounds in drinking water by gas chromatography-triple quadrupole tandem mass spectrometry

目的建立同时测定饮用水中氯乙烯、1,1-二氯乙烯、二氯甲烷、反-1,2-二氯乙烯、顺-1,2-二氯乙烯、三氯甲烷、1,1,1-三氯乙烷、1,2-二氯乙烷、苯、四氯化碳、三氯乙烯、二氯一溴甲烷、甲苯、一氯二溴甲烷、四氯乙烯、乙苯、对二甲苯、间二甲苯、苯乙烯、邻二甲苯、三溴甲烷和异丙苯的吹扫捕集-气相色谱-三重四级杆串联质谱法(GC-MS/MS)。方法取5 ml水样,以高纯氮气为载气在40 ml/min流速下吹扫7 min后,热解吸进入GC-MS/MS进行分析,以多反应监测模式(MRM)进行检测,外标法定量。同时对影响吹扫捕集效率的吹扫时间和吹扫流速进行了优化。结果在本实验条件下,方法的线性相关系数(r)大于0.996,相对标准偏差(RSD)为0.99%~9.88%,平均加标回收率为80.1%~93.1%(n=3)。结论本方法简便、快速、灵敏度高,能在短时间内准确定性定量分析生活饮用水中22种挥发性有机物。

Objective To establish a method for simultaneous quantitative detection of vinyl chloride,1,1-dichloroethylene,methylene chroride,trans-1,2-dichloroethylene,cis-1,2-dichloroethylene,chloroform,1,1,1-trichloroethane,1,2-dichloroethane,benzene,carbon tetrachloride,trichloroethylene,bromodichrolomethane,toluene,dibromochrolomethane,tetrachloroethylene,ethylbenzene,p-xylene,m-xylene,styrene,o-xylene,bromoform and isopropylbenzene in drinking water by gas chromatography-triple quadrupole tandem mass spectrometry（ GC-MS/MS）. Methods 5 ml of water sample was purged by 40 ml/min high pure nitrogen for 7 min,then desorbed and analyzed by GC-MS/MS. Multiple reaction monitoring mode（ MRM） was performed for test,and external standard method was used for quantification. The effects of purge time and purge flow were optimized. Results Under the condition,the correlation coefficient（ r） of 22 volatile organic compounds were greater than 0. 996,the relative standard deviations（ RSD） were from 0. 99% to 9. 88%,and the recovery of three spiking levels were within 80. 1%-93. 1%（ n = 3）. Conclusion The developed method is simple,rapid and sensitive. Using the method,22 kinds of volatile organic compounds can be simultaneously determined in short time.