雷公藤甲素抗肿瘤药理作用的研究进展

Research progress on pharmacological effects of triptolide against tumor

雷公藤甲素是从中药雷公藤中提取的一种具有多种生物活性的天然产物,是雷公藤片、雷公藤多甙片等制剂的主要有效成分,临床多用于抗炎及免疫抑制。药理研究表明雷公藤甲素还具有广谱、高效的抗肿瘤活性,作用机制涉及诱导细胞凋亡、阻滞细胞周期、逆转肿瘤细胞多药耐药等多个方面。综述了雷公藤甲素对消化系统、生殖系统、血液系统、呼吸系统肿瘤的抗肿瘤作用及相关机制的研究进展,为加速其抗肿瘤新药研发提供理论依据。

Triptolide,extracted from Chinese herb Tripterygium wilfordii,is a natural product with multiple biological activities,which is the main effective component in preparations of T.wilfordii tablets and T.wilfordii polyglycoside tablets used for anti-inflammatory and immunosuppression in clinic.Pharmacological studies show that triptolide has a broad spectrum and high efficient antitumor activity.The mechanism of action involves inducing apoptosis,blocking cell cycle and reversing multidrug-resistance of tumor cells.This review summarizes the research progress of antitumor activities and related mechanisms of triptolide in the digestive system,reproductive system,hematological system,respiratory system,so as to provide a theoretical basis for speeding up the development of new antitumor drugs.