多糖包被及其在失血性休克发展进程中的作用

Glycocalyx and its role during hemorrhagic shock

多糖包被是血管内皮双层屏障的重要组成部分，具有抗炎、抗凝等生理功能；失血性休克引起多糖包被的结构破坏，进而在血管高通透性、过度炎症反应、血液高凝的发生过程中发挥重要作用，成为失血性休克发生机制之一。本文综述多糖包被的结构、功能及其在失血性休克发展进程中的作用，为以多糖包被为切入点，防治失血性休克提供新思路。

The glycocalyx is an important component of endothelial double barrier, has various physiological functions includes anti -inflammation and anti -coagulation, etc. Hemorrhagic shock induces the damage of glycocalyx, which plays important roles in the vascular hyper - permeability, excessive infammation, and increased blood coagulation, and becomes one of mechanisms by which refractory hemorrhagic shock. The current article reviews the structure and function of glycocalyx and its role during hemorrhagic shock, thus, provides a novel approach for treatment of hemorrhagic shock basing on glycocalyx.