粘蛋白2在结直肠癌中的表达及其研究进展

Research advances of the expression of Mucin 2 in colorectal cancer

黏蛋白2作为肠道粘膜的一种主要的保护性蛋白,其主要存在于杯状细胞中,在生理状态下其可以帮助肠道粘膜抵御外界有害因素的侵入。近几年来研究发现,黏蛋白2与结肠癌的发生、发展、转移及预后密切相关,推测其可作为结肠癌临床诊治的新靶标。本文就黏蛋白2与结直肠癌的表达及发生发展的相关研究进展进行综述。

Mucin 2 is a major protective protein for intestinal mucosa,which is mainly expressed in goblet cells,and helps intestinal mucosa to resist the invasion of harmful factors in the physiological state. In recent years,it has been found that Mucin 2 is closely related to the occurrence,development,metastasis and prognosis of colon cancer. It is suggested that Mucin 2 can be used as a new target for clinical diagnosis and treatment of colon cancer. This review summarizes the relevant studies concerning the relationship between the expression of Mucin 2 and the development of colorectal cancer.