咽部微生态失调与常见呼吸道疾病

Disorder of pharyngeal microbiota and respiratory diseases

咽部微生态的动态平衡是决定呼吸道健康的重要因素之一。越来越多的证据表明，咽部微生物群在多种呼吸道疾病的发生、发展中发挥着重要的作用，与慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）、哮喘、呼吸道感染性疾病、肺囊性纤维化（cystic pulmonary fibrosis，CF）以及结核病（tuberculosis，TB）等疾病的临床表现、急性加重、严重程度、治疗以及预后相关。因而研究人体咽部微生态失调与常见呼吸道疾病相关性具有重要意义。

The balance of the pharyngeal microbiota is one of the important factors for the respiratory tract health. There is growing evidence that the pharyngeal microbiome has an important effect on the develop- ment and progression of respiratory diseases. The features of pharyngeal mierobiome are associated with clinical phenotypes, acute exacerbation, severity, treatment and prognosis of chronic obstructive pulmonary disease （ COPD ） , asthma, respiratory infectious diseases, cystic fibrosis （ CF ） and tuberculosis （ TB ）. Therefore, it is of great significance to study the relationship between human pharyngeal mierobiota disorder and common respira- tory diseases.