异种肺移植的细胞免疫排斥反应

Cellular immune rejection response of lung xenotransplantation

肺移植是很多终末期肺疾病唯一有效的治疗方式。由于肺独特的解剖和生理因素，供体肺获取的数量要远小于其他器官，肺源短缺一直以来是肺移植未能广泛开展的重要原因。异种肺移植可能是一种解决肺器官短缺的有效途径，但肺异种移植过程中的细胞免疫排斥反应一直是制约肺异种移植能否成功的关键因素之一。通过对免疫细胞的深入研究可能使异种肺移植取得新的进展。

Lung transplantation is the only effective treatment for many end-stage lung diseases. The number of donor lung is far less than the other organs because of the unique anatomy and physiological factors of the lung, which is the important reason for the failure of lung transplantation. The lung xenotransplantation may be an effective way to solve the shortage of lung organs, but cellular immune rejection response has been one of the key factors that restricting the success of the lung xenotransplantation. Researches on immune cells would definitely promote the progress of lung xenotransplantation.