血清长正五聚蛋白3及C反应蛋白在AECOPD患者中的水平及临床意义

Changes and clinical significance of serum long pentraxin3(PTX3)and CRP levels in patients with acute exacerbation of chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者血清长正五聚蛋白3(PTX3)及C反应蛋白(CRP)水平变化及其临床意义。方法连续入选135例AECOPD患者并按《慢性阻塞性肺疾病全球倡议标准》(GOLD)分为GOLD1、GOLD2、GOLD3、GOLD4四亚组,同期选取75例健康体检者作为对照组,分别测定肺功能第1秒用力呼气容积(FEV1)与用力肺活量(FVC)比值(FEV1/FVC)及血清PTX3、CRP水平,比较AECOPD组与健康对照组及AECOPD各亚组间的PTX3、CRP水平,并作Pearson相关性分析。结果 AECOPD组的血清PTX3及CRP水平均高于健康对照组,且差异均具有统计学意义(P<0.05);血清PTX3及CRP水平由高到低依次为GOLD4>GOLD3>GOLD2>GOLD1>健康对照组,AECOPD各亚组间差异具有统计学意义(P<0.05);血清PTX3、CRP水平均与FEV1预测值呈负相关(r=-0.37、-0.76,P<0.05);血清PTX3、CRP水平均与FEV1/FVC呈负相关(r=-0.29、-0.65,P<0.05)。结论血清PTX3和CRP水平均有助于AECOPD的早期诊断。PTX3、CRP水平与AECOPD的严重程度相关,可用于评估AECOPD患者的病情。

Objective To explore the changes and clinical significance of serum long pentraxin3（PTX3）and C-reaction protein（CRP）levels in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods A total of 135 AECOPD patients were selected and divided into 4 subgroups according to global initiative for chronic obstructive lung disease（GOLD）standard. 75 health people were selected as control group. Serum levels of PTX3 and CRP,and the ratio of forced expiratory volume in one second（FEV1） to forced vital capacity（FVC）（FEV1/FVC） were measured after pulmonary function test. Levels of PTX3 and CRP between AECOPD and control group or within AECOPD subgroups were compared. Pearson correlation analysis was performed using SPSS 22.0. Results Serum levels of PTX3 and CRP in AECOPD group were significantly higher than those in control group（P〈0.05）. Serum levels of PTX3 and CRP levels from high to low were in GOLD4,GOLD 3,GOLD 2,GOLD 1 and control group. There were significant differences in serum PTX3 level and serum CRP level among AECOPD subgroups（P〈0.05）. Both PTX3 and CRP levels were negatively correlated with FEV1（r=-0.37、-0.76,P〈0.05）or with FEV1/FVC（r=-0.29、-0.65,P〈0.05）. Conclusion Serum levels of PTX3 and CRP can be used for early diagnosis and evaluation of AECOPD since it is correlated with severity of AECOPD.