摘要
目的观察盐酸非索非那定片递减疗法治疗慢性自发性荨麻疹的疗效。方法选取我院2015年5月至2016年12月收治的96例慢性自发性荨麻疹患者,随机分为对照组及干预组各48例。对照组采用盐酸非索非那定片120 mg/d治疗12周,干预组前4周采用盐酸非索非那定片120 mg/d,第5周和第9周进行逐渐减量治疗。观察两组患者治疗前、治疗6周和12周后的荨麻疹活动性评分(UAS)、皮肤病生活质量指标(DLQI)评分和总服药量。结果治疗前,两组患者的UAS、DLQI评分比较差异均无统计学意义(P>0.05);治疗6周及12周后,两组患者的UAS、DLQI评分均低于治疗前(P<0.05),但两组患者的UAS、DLQI评分比较差异均无统计学意义(P>0.05)。治疗6周及12周后,干预组的总服药量明显低于对照组(P<0.05)。所有患者均耐受性良好,两组患者的不良反应发生率比较差异无统计学意义(P>0.05)。结论采用盐酸非索非那定片递减疗法治疗慢性自发性荨麻疹患者的疗效与常规剂量相当,能够减少药物使用剂量,且不会增加患者的不良反应,节省医疗资源,值得临床推广应用。
Objective To observe the curative effect of degression therapy of fexofenadine hydroehloride tablets in the treatment of chronic spontaneous urticaria. Methods 96 cases of patients with chronic spontaneous urticaria admitted to our hospital from May 2015 to December 2016 were selected and randomly divided into control group and intervention group, with 48 cases in each group. The control group took fexofenadine hydrochloride tablets 120 mg/d for 12 weeks, while the intervention group took fexofenadine hydrochloride tablets 120 mg/d in the first four weeks, and received tapering treatment in the fifth week and the ninth week. The urticaria activity score (UAS), the dermatology life quality index (DLQI) score and total dosage of two groups before treatment, 6 weeks and 12 weeks after treatment were observed. Results No statistical difference was found in the UAS and DLQI score between the two groups before treatment (P 〉0.05). 6 weeks and 12 weeks after treatment, the UAS and DLQI score of both groups were significantly lower than those before treatment (P〈0.05), but no statistical difference was found in the UAS and DLQI score between the two groups (P〉0.05). 6 weeks and 12 weeks after treatment, the total dosage of the intervention group was significantly lower than that of the control group (P 〈0.05). All patients were well tolerated. No statistical difference was found in the incidence of adverse reactions between the two groups (P〉0.05). Conclusions Degression therapy of fexofenadine hydrochloride tablets in the treatment of patients with chronic spontaneous urticaria has the equivalent effect compared with conventional dose, can reduce the dosage of drugs, and save the medical resources without increasing the adverse reactions of patients, which is worthy of clinical promotion and application.
作者
文双平
WEN Shuangping(Department of Dermatology, the People's Hospital of Anxiang County, Changde 415600, Chin)
出处
《临床医学工程》
2018年第3期319-320,共2页
Clinical Medicine & Engineering
关键词
慢性自发性荨麻疹
盐酸非索非那定
递减疗法
疗效
剂量
Chronic spontaneous urticaria
Fexofenadine hydrochloride
Degression therapy
Curative effect
Dosage