成年癫痫患者部分性发作与全身性发作的生态执行功能及对其生活质量的影响

Ecological Executive Function of Partial and Generalized Seizures in Adult Epileptic Patients and the Influence on Quality of Life

目的研究成年癫痫患者部分性发作与全身性发作的生态执行功能及对其生活质量的影响。方法选取我院收治的成年癫痫患者部分性发作80例与全身性发作80例,并选取同期在我院体检的健康成年男性80例作为对照组,采用执行功能行为评定量表成人版(BRIEF-A)评估其执行功能,同时采用癫痫患者生活质量量表(QOLIE-31)评估其生活质量。结果部分性发作组和全身性发作组的BRIEF-A评分均明显高于对照组(P<0.05),且部分性发作组的BRIEF-A评分明显低于全身性发作组(P<0.05)。部分性发作组和全身性发作组的QOLIE-31评分明显低于对照组(P<0.05),且部分性发作组的QOLIE-31评分明显高于全身性发作组(P<0.05)。结论长时间疾病的反复发作对成年癫痫患者的认知功能、生态执行功能等均造成严重损伤,对其生活质量影响较大,因此临床治疗不能仅限于控制疾病发作,更应重视其认知功能的恢复。

Objective To study the ecological executive function of partial and generalized seizures in adult epileptic patients and the influence on quality of life. Methods 80 cases of adults with partial seizures of epilepsy and 80 cases of adults with generalized seizures of epilepsy in our hospital were selected. 80 healthy adult males undergoing physical examination in our hospital were selected as the control group. The behavior rating inventory of executive function-adult version （BRIEF-A） was used to evaluate their executive function. The quality of life in epilepsy inventory-31 items （QOLIE-31） was used to evaluate their quality of life. Results The BRIEF-A scores of the partial seizure group and generalized seizure group were significantly higher than those of the control group （P〈0.05）; The BRIEF-A scores of the partial seizure group were significantly lower than those of the generalized seizure group （P 〈0.05）. The QOLIE-31 scores of the partial seizure group and generalized seizure group were significantly lower than those of the control group （P〈0.05）; The QOLIE-31 scores of the partial seizure group were significantly higher than those of the generalized seizure group （P 〈0.05）. Conclusions For adult patients with epilepsy, the repeated seizures cause the severe injury in their cognitive function and ecological executive function, which have great influence on their quality of life. Therefore, the clinical treatment should not be limited to control the seizures, but should pay more attention on the recovery of cognitive function.