摘要
One-pot two-step stepwise reaction of terminal propargylic alcohols, carbon dioxide, and primary/secondary amines for the effective synthesis of various urethanes through robust silver-catalysed C-O/C-N bond formation is reported, Catalytic activities were investigated by controlling catalyst loading, reaction pressure and time, and very high turnover number （turnover frequency） was obtained： 3350 （35 h-1） with 0.01 mol% silver catalyst under 0.1 MPa, and up to 13360 （139 h-1） with 0.005 mol% silver catalyst under 2.0 MPa at room temperature. The strategy was ingeniously regulated, and synchronously afforded a wide range of β-oxopropylcarbamate and 1,3-oxazolidin-2-one motifs in excellent yields and selectivity together with unprecedented high turnover number （TON） and turnover frequency （TOF） value.
One-pot two-step stepwise reaction of terminal propargylic alcohols, carbon dioxide, and primary/secondary amines for the effective synthesis of various urethanes through robust silver-catalysed C-O/C-N bond formation is reported, Catalytic activities were investigated by controlling catalyst loading, reaction pressure and time, and very high turnover number （turnover frequency） was obtained： 3350 （35 h-1） with 0.01 mol% silver catalyst under 0.1 MPa, and up to 13360 （139 h-1） with 0.005 mol% silver catalyst under 2.0 MPa at room temperature. The strategy was ingeniously regulated, and synchronously afforded a wide range of β-oxopropylcarbamate and 1,3-oxazolidin-2-one motifs in excellent yields and selectivity together with unprecedented high turnover number （TON） and turnover frequency （TOF） value.
基金
We are grateful to the National Natural Science Foundation of China （21602232）, the Natural Science Foundation for Youths of Shanxi （201701D221057）, and the Project of ＂Utilization of Low Rank Coal＂ Strategic Leading Special Fund, Chinese Academy of Sciences （XDA-07070800, XDA-07070400）.
